The meningeal lymphatic vessels are potential targets for treating brain diseases. Laboratories at Yale University and the Paris Brain Institute (Hospital Petit-Salpetriere, Paris) have imaged brain drainage by the meningeal lymphatic vessels in mice and humans.
at recent days Journal of Experimental Medicine A paper led by Jean-Leon Thomas, PhD, professor of neuroscience, and Ann Eichmann, PhD, professor of medicine and professor of cellular and molecular physiology and co-director of the Yale University Cardiovascular Research Center (YCVRC), demonstrates that cerebrospinal fluid drainage pathways are similar between mice and humans. A new imaging technique based on magnetic resonance imaging for patients with neurological diseases.
The lymphatic vascular system controls immune monitoring and waste disposal within tissues and organs. Lymphatic vessels are absent from the central nervous system (CNS) but are present at the border of the central nervous system, in the meninges that protect the brain and spinal cord. The meningeal lymphatic vessels drain into the neck lymph nodes and the peripheral immune system, making them major players in controlling brain immunity.
The meningeal lymphatic vessels are also important for the removal of waste products from the brain, by participating in the removal of interstitial fluid and soluble proteins, as well as in the drainage of cerebrospinal fluid that provides the brain with a protective barrier of fluid against injury, a necessary pathway. Nutrients and cellular waste disposal system.
The meningeal lymphatic system affects neurodegenerative diseases in several mouse models, including Alzheimer’s disease, multiple sclerosis, brain tumors, and other conditions. “Because of its implication in many diseases, the meningeal lymphatic system has attracted a lot of therapeutic interest,” explains Laurent Jacob, PhD, first author of the study and a member of the research team in Paris.
“However, it remains unclear where the lymphatic recovery of cerebrospinal fluid particles occurs in the context of the whole head, in mice or in humans.”
To learn more about the structure and function of the meningeal lymphatic network, the team investigated the lymphatic drainage of cerebrospinal fluid using post-mortem photoacoustic platelet imaging in mice and magnetic resonance imaging in humans. By combining these approaches, the authors reconstructed the entire lymphatic drainage network of cerebrospinal fluid.
3D imaging showed that the meningeal lymphoid contacts the venous sinuses of the dura mater, revealing an extensive meningeal lymphatic network around the cavernous sinus in the anterior part of the skull. From there, the meningeal lymph exits the skull through the cranial foramen and drains into the cervical lymph nodes.
Stephanie Link, MD, also at Pitié-Salpêtrière Hospital, performed quantitative MRI in 11 patients with various neurological diseases. established a procedure for 3D visualization of all blood and lymphatic vessels in the meninges and neck which revealed a significantly larger meningeal lymphatic volume in men than in women.
Future research will have to explore whether these anatomical data are causally related to women’s greater predisposition to neurological diseases such as multiple sclerosis, meningiomas or intracranial hypertension.
“The meningeal lymphatic vessels are potential targets for treating brain diseases,” Eichmann said. Laboratories at Yale University are making progress toward elucidating its function by imaging brain drainage by meningeal lymph in mice and humans.
About this Neuroscience Research News
author: Elizabeth Reitman
Contact: Elizabeth Reitman – Yale
picture: The image is attributed to the researchers
original search: open access.
“Conserved meningeal lymphatic drainage circuits in mice and humans” by Laurent Jacob et al. Journal of Experimental Medicine
Conserved meningeal lymphatic drainage circuits in mice and humans
Meningeal lymphatic vessels (MLVs) were identified in the dorsal and caudal regions of the dura mater, where they ensured elimination of waste products and immune monitoring of brain tissue. It remains unclear whether MLVs are located in the anterior part of the human and mouse skull and how they relate to the glymphatic system and extracranial lymphatic vessels.
Here, we used light leaf microscopy (LSFM) imaging of whole mouse preparations after OVA-A555 Tracer injection into cerebrospinal fluid (CSF) and real-time magnetic resonance imaging (VW-MRI) after systemic injection of gadobuterol in patients with neurological diseases.
We observed a preserved 3D anatomy of MLVs in mice and humans consistent with the dural venous sinuses but not with the outflow of nasal cerebrospinal fluid, and detected an anterior MLV network extending around the cavernous sinus, with exit routes through perforating scattered veins. VW-MRI may provide a diagnostic tool for patients with cerebrospinal fluid drainage defects and neurological diseases.