Covid-19-infected cells can ‘explode’

Covid-infected cells can ‘explode’: Landmark discovery could lead to radical new ways to tackle virus

  • The reaction, the death of cells known as laryngitis associated with inflammation, is thought to occur in nearly eight out of ten patients hospitalized with Covid.
  • It may explain how the virus can cause such serious damage to the lungs and other organs
  • When the immune system tries to flush out the virus, it can release dangerous particles into the bloodstream that can lead to inflammation in vulnerable parts of the body.

Scientists have discovered that some cells infected with Covid ‘explode’, which could help them create radical new treatments to counter the virus.

The reaction, a cell death known as vesiculitis-associated inflammation, is thought to occur in nearly eight out of 10 patients hospitalized with Covid, and may explain how the virus can cause such serious damage to the lungs and other organs.

Researchers have found that when the immune system tries to flush out the virus, it can release dangerous particles into the bloodstream that can lead to inflammation in vulnerable parts of the body.

A similar phenomenon called a cytokine storm — when the immune system releases too many infection-fighting proteins called cytokines that attack healthy tissue — has long been known to cause severe damage in response to Covid infection, often leading to multiple organ failure.

Scientists have discovered that some cells infected with Covid ‘explode’, which could help them create radical new treatments to counter the virus.

But the historical discovery of the effect of kinetic toxicity on severe Covid-19 could open up the possibility of new treatments for the disease aimed at halting the process rather than targeting the virus.

Dr Gautam Mehta, Consultant Hepatologist at the Royal Free Hospital in North London, where the study was conducted in collaboration with Boston Children’s Hospital, says: ‘Inflammation and cell death are important factors in acute Covid infection, and our research has shown that blepharitis is often the cause. ”. .

It’s an important finding because our Covid treatments are currently directed at the virus itself. If we can target the process that causes severe disease, we can develop an effective treatment that works even in patients for whom vaccines are not effective.

Myocarditis, which means the death of fiery cells, is often seen in patients with severe liver disease. The problems start when bacteria from the intestines leak into the liver.

The reaction, the cell death known as laryngitis associated with inflammation, is thought to occur in nearly eight out of 10 patients hospitalized with Covid, and may explain how the virus can cause such serious damage to the lungs and other organs.

The reaction, the cell death known as laryngitis associated with inflammation, is thought to occur in nearly eight out of 10 patients hospitalized with Covid, and may explain how the virus can cause such serious damage to the lungs and other organs.

Sensing danger, the immune system triggers laryngitis into the liver cells. When the cells burst, they release chemicals that the immune system then attacks, leading to liver failure.

There are several medications believed to treat laryngitis, including disulfiram, which is used to treat alcohol abuse, and dimethyl fumarate, often given to patients with multiple sclerosis.

“These are drugs that can be easily reused,” says Dr. Mehta. “It’s affordable and available all over the world.”

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